Fetal Calf Serum (FCS, also known as Fetal Bovine Serum, or FBS) is a common supplement of animal cell culture media. However, FCS is harvested, with a high chance of suffering, from bovine foetuses taken from pregnant cows during slaughter. Furthermore, since it is a natural product, the composition of the commercially available FCS varies from batch to batch, which impedes the reproducibility of results. These moral and scientific concerns demonstrate the urgency to switch to an FCS-free medium. The FCS-free Database provides an overview of the range of commercially available serum-free media for cell-culture, as well as medium compositions obtained from scientific literature. Additionally, the forum function allows researchers to discuss on the applicability of each product. The database is offered by the 3Rs-Centre ULS in collaboration with Animal Free Research UK.
When mentioning the fcs-free.org database please also use its RRID: SCR_018769
If you want to read more about the objections against FCS, visit the references and reviews articles page.
The FCS-free Database is part of the 3Rs Database Programme, together with www.humane-endpoints.info, and www.interspeciesinfo.com. These websites provide information that enables researchers to refine and reduce animal experiments, respectively.
If you have any questions or remarks concerning the FCS-free Database, or if you wish to add a product to our website, please do not hesitate to contact us.